Biografía
Education: Ph. D. in Biochemistry and Molecular Biology (1994), Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Spain
Career:
●Staff CSIC since 2006. Instituto de Biologia Molecular y Celular de Plantas. In 2009 promoted to Research Scientist. In 2016 promoted to Research Professor.
●Assistant Professor of Biochemistry and Molecular Biology, 2003-2006. Universidad Politecnica de Valencia
●Ramon y Cajal Postdoctoral fellow, 1998-2003. Laboratory of Prof. Ramon Serrano, Universidad Politecnica de Valencia.
●EMBO postdoctoral fellow, 1995-1997. Laboratory of Prof. Erwin Grill, ETH Zurich, Switzerland/ TU Munich, Germany.
Author of >80 articles, 3 patents, participation in 27 projects (14 as PI), Associate Editor in Molecular Plant, Highly Cited Researcher 2015, 2016 by Thomson Reuters ranking among the top 1% most cited for their subject field. Dr. Rodriguez is a leader in ABA signaling, with particular emphasis in the biotechnological potential of the pathway to improve plant tolerance to drought and salinity. He has played a key role in the discovery and characterization of the new family of PYR/PYL ABA receptors and their connection with PP2Cs and SnRK2s.
Publicaciones destacadas
Rodriguez PL (2016). ABA catabolism generates PA, a molecule able to activate a subset of ABA receptors. Molecular Plant 9, 1448-1450
Wu,Q., Zhang,X., Peirats-Llobet,M., Belda-Palazon,B., Wang,X., Cui,S., Yu,X., Rodriguez,P.L.* (corresponding author) and An,C. (2016). Ubiquitin Ligases RGLG1 and RGLG5 Regulate Abscisic Acid Signaling by Controlling the Turnover of Phosphatase PP2CA. Plant Cell pii: tpc.00364.2016
Belda-Palazon,B., Rodriguez,L., Fernandez,M.A., Castillo,M.C., Anderson,E.A., Gao,C., Gonzalez-Guzman,M., Peirats-Llobet,M., Zhao,Q., De Winne,N., Gevaert,K., De Jaeger,G., Jiang,L., Leon,J., Mullen,R.T. and Rodriguez,P.L. (2016). FYVE1/FREE1 Interacts with the PYL4 ABA Receptor and Mediates its Delivery to the Vacuolar Degradation Pathway. Plant Cell pii: tpc.00178.2016
Antoni,R., Dietrich,D., Bennett,M.J. and Rodriguez,P.L. (2016). Hydrotropism: Analysis of the Root Response to a Moisture Gradient. Methods Mol. Biol. 1398, 3-9.
Diaz,M., Sanchez-Barrena,M.J., Gonzalez-Rubio,J.M., Rodriguez,L., Fernandez,D., Antoni,R., Yunta,C., Belda-Palazon,B., Gonzalez-Guzman,M., Peirats-Llobet,M., Menendez,M., Boskovic,J., Marquez,J.A., Rodriguez,P.L. and Albert,A. (2016). Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling. PNAS Jan 19;113(3):E396-405
Peirats-Llobet,M., Han,S.K., Gonzalez-Guzman,M., Jeong,C.W., Rodriguez,L., Belda-Palazon,B., Wagner,D. and Rodriguez,P.L. (2016). A direct link between abscisic acid sensing and the chromatin remodeling ATPase BRAHMA via core ABA signaling pathway components. Mol Plant. 9(1):136-47.
Rodriguez, P.L. and Lozano-Juste, J. (2015). Unnatural agrochemical ligands for engineered abscisic acid receptors. Trends in Plant Science 20(6):330-2.
Gonzalez-Guzman,M., Rodriguez,L., Lorenzo-Orts,L., Pons,C., Sarrion-Perdigones,A., Fernandez,M.A., Peirats-Llobet,M., Forment,J., Moreno-Alvero,M., Cutler,S.R., Albert,A., Granell,A. and Rodriguez,P.L. (2014). Tomato PYR/PYL/RCAR abscisic acid receptors show high expression in root, differential sensitivity to the abscisic acid agonist quinabactin, and the capability to enhance plant drought resistance. J Exp Bot 65, 4451-4464.
Bueso E, Rodriguez L, Lorenzo-Orts L, Gonzalez-Guzman M, Sayas E, Muñoz-Bertomeu J, Ibañez C, Serrano R, Rodriguez P.L. (2014) The single subunit RING-type E3 ubiquitin ligase RSL1 targets PYL4 and PYR1 ABA receptors in plasma membrane to modulate abscisic acid signaling. Plant J. 80, 1057-1071.
Rodriguez, L., Gonzalez-Guzman, M., Diaz, M., Rodrigues, A., Peirats-Llobet, M., Izquierdo-Garcia, A.C., Antoni, R., Marquez, J.A. Mulet, J.M. Albert, A. and Rodriguez P.L. (2014). C2-domain abscisic acid-related proteins mediate the interaction of PYR/PYL/RCAR abscisic acid receptors with the plasma membrane. Plant Cell 26, 26(12):4802-20
Pizzio, G.A., Rodriguez, L., Antoni, R., Gonzalez-Guzman, M., Yunta, C., Merilo, E., Kollist, H., Albert, A., Rodriguez P.L. (2013) The PYL4 A194T mutant uncovers a key role of PYL4-PP2CA interaction for ABA signaling and plant drought resistance. Plant Physiology 163: 441-455.
Antoni, R., Gonzalez-Guzman, M., Rodriguez, L., Peirats-Llobet, M., Pizzio, G.A., Fernandez, M.A., De Winne N., De Jaeger G., Dietrich, D., Bennett M.J., Rodriguez P.L (2013). PYRABACTIN RESISTANCE1-LIKE8 plays an important role for the regulation of abscisic acid signaling in root. Plant Physiology 161: 931-941.
Gonzalez-Guzman, M., Pizzio, G.A, Antoni, R., Vera-Sirera, F., Merilo, E., Bassel, G.W., Fernandez, M.A., Holdsworth, M., Perez-Amador, M.A., Kollist, H. and Rodriguez, P.L (2012). Abscisic acid perception via PYR/PYL/RCAR receptors plays a major role to regulate stomatal aperture and ABA transcriptional response. Plant Cell 24: 2483-2496.
Antoni, R., Gonzalez-Guzman, M., Rodriguez, L., Rodrigues, A., Pizzio, G.A. and Rodriguez, P.L (2012). Selective inhibition of clade A phosphatases type 2C by PYR/RCAR/RCAR abscisic acid receptors Plant Physiology 158, 970-980.
Dupeux, F., Antoni, R., Betz, K., Santiago, J., Gonzalez-Guzman, M., Rodriguez, L., Rubio, S., Park, S-Y., Cutler, S.R., Rodriguez, P.L* (corresponding author) and Marquez, J.A. (2011). Modulation of ABA signaling in vivo by an engineered receptor-insensitive PP2C allele. Plant Physiology 156, 106-116.
Cutler, S.R., Rodriguez, P.L., Finkelstein, R.R., Abrams, S.R. (2010). Abscisic acid: emergence of a core signaling network. Annu. Rev. Plant Biol. 61, 651-679.
Santiago, J., Rodrigues, A., Saez, A., Rubio, S., Antoni, R., Park, S-Y., Dupeux, F., Marquez, J.A., Cutler, S.R. and Rodriguez, P.L. (2009). Modulation of drought resistance by the abscisic acid-receptor PYL5 through inhibition of clade A PP2Cs. Plant J 60, 575-588.
Rubio, S., Rodrigues, A., Saez, A., Dizon, M.B., Galle, A., Kim, T., Santiago, J., Flexas, J., Schroeder, J.I.S. and Rodriguez, P.L. (2009). Triple loss-of-function of protein phosphatases type 2C leads to partial constitutive response to endogenous ABA. Plant Physiology 150, 1345-1355.
Santiago, J., Dupeux, F., Round, A., Antoni, R., Park, S-Y., Jamin, M., Cutler, S.R., Rodriguez, P.L. and Marquez, J.A. (2009). The abscisic acid receptor PYR1 in complex with abscisic acid. Nature 462, 660-664
Fujii, H., Chinnusamy, V., Rodrigues, A., Rubio, S., Antoni, R., Park, S-Y., Cutler, S.R., Sheen, J., Rodriguez, P.L. and Zhu, J-K. (2009). In vitro reconstitution of an ABA signalling pathway. Nature 462, 665-668.
Park, S-Y., Fung, P., Nishimura, N., Jensen, D.R., Fujii, H., Zhao, Y., Lumba, S., Santiago, J., Rodrigues, A., Chow, T-S., Alfred, S.E., Bonetta, D., Finkelstein, R., Provart, N.J., Desveaux, D., Rodriguez, P.L., McCourt, P., Zhu, J-K, Schroeder, J.I., Volkman, B.F. and Cutler, S.R. (2009). Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of ABA-binding START proteins. Science 324, 1068-1071.
Saez, A., Rodrigues, A, Santiago, J., Rubio, S. and Rodríguez, P.L. (2008). HAB1-SWI3B interaction reveals a link between abscisic acid signaling and putative SWI/SNF chromatin remodeling complexes. Plant Cell 20, 2972-2988.
Saez, A., Robert, N., Maktabi, M., Schroeder, J.I, Serrano, R. and Rodriguez, P.L. (2006). Enhancement of abscisic acid sensitivity and reduction of water consumption in Arabidopsis by combined inactivation of the protein phosphatases type 2C ABI1 and HAB1. Plant Physiol 141, 1389-1399.
Saez, A., Apostolova, N., Gonzalez-Guzman, M., Gonzalez-Garcia, M.P., Nicolas, C., Lorenzo, O. and Rodriguez, P.L. (2004). Gain-of-function and loss-of-function phenotypes of the protein phosphatase 2C HAB1 reveal its role as a negative regulator of abscisic acid signalling. Plant J 37, 354-369.
Gonzalez-Guzman, M., Apostolova, N., Belles, J.M., Barrero, J.M., Piqueras, P., Ponce, M.R., Micol, J.L., Serrano, R. and Rodriguez, P.L. (2002). The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin to abscisic aldehyde. Plant Cell 14, 1833-1846.